Little Orphan Annie was adapted to a 15-minute radio show that debuted on WGN Chicago in 1930 and went national on NBC‘s Blue Network. It was one of the first
comic strips adapted to radio and the first late-afternoon children’s serial. It had
about 6 million fans, and left the air in 1942. 

when the show debuted, radio had yet to establish coast-to-coast networks so
two separate casts performed—one in San Francisco starring Floy Margaret
Hughes and the other in Chicago with Shirley Bell as Annie, Stanley Andrews
as "Daddy", and Allan Baruck (and later Mel Tormé) as Joe Corntassel.

When coast to coast networking was established in 1933, the Chicago cast
became the permanent one. Announcer Pierre Andre provided Sandy’s "Arf!"
and sang the theme (as Uncle Andy).

    
Pierre Andre                                    Stanley Andrews